LOCOST is a not-for-profit organization that was set up to make available essential medicines of quality at reduced costs by eliminating the margins shared with prescribers, distributors and middlemen, and related marketing costs. Registered as Low-Cost Standard Therapeutics in 1983, but better known as LOCOST, it is a public charitable trust that is concerned with public health aspects of medicines: their genesis, costs, clinical trials, licensing, patenting, production, distribution and consumption till it reaches the end user, namely the patient. LOCOST is also concerned about the long-term impact of medicines – their use, misuse and overuse, adverse reactions and side effects - and the public regulation of all related issues.